Voltage Dependence of a Neuromodulator-Activated Ionic Current
نویسندگان
چکیده
منابع مشابه
Voltage Dependence of a Neuromodulator-Activated Ionic Current123
The neuromodulatory inward current (IMI) generated by crab Cancer borealis stomatogastric ganglion neurons is an inward current whose voltage dependence has been shown to be crucial in the activation of oscillatory activity of the pyloric network of this system. It has been previously shown that IMI loses its voltage dependence in conditions of low extracellular calcium, but that this effect ap...
متن کاملVoltage dependence of the Ca2+-activated cation channel TRPM4.
TRPM4 is a Ca2+-activated but Ca2+-impermeable cation channel. An increase of [Ca2+]i induces activation and subsequent reduction of currents through TRPM4 channels. This inactivation is strikingly decreased in cell-free patches. In whole cell and cell-free configuration, currents through TRPM4 deactivate rapidly at negative potentials. At positive potentials, currents are much larger and activ...
متن کاملA Low Voltage Switched-Capacitor Current Reference Circuit with low dependence on Process, Voltage and Temperature
A low voltage switched-capacitor circuit that generates an almost constant reference current across process, voltage and temperature (PVT) is proposed. The reference voltage is generated by a low voltage band-gap circuit. The output reference current is obtained by applying the generated reference voltage to a low voltage V – I converter. The resistor in the proposed V – I converter is further ...
متن کاملLead inhibits the voltage-activated calcium current of Aplysia neurons.
Lead is a potent and reversible inhibitor of the voltage-dependent calcium current of Aplysia neurons in a concentration range (1-1000 microM) similar to that which elicits toxic effects in man. The threshold for inhibition is 1 microM and the dissociation constant about 90 microM. The inhibition is due to reduction of the peak current amplitude, and not due to alteration of the voltage depende...
متن کاملZn2+ blocks the voltage activated calcium current of Aplysia neurons.
We have investigated the effect of Zn2+ on voltage-activated calcium currents of Aplysia neurons, using conventional two-electrode voltage-clamp techniques. The peak of these currents was reversibly reduced by Zn2+ (50% reduction at 3.75 mM; total block at 20 mM), while the current-voltage relation and the activation and inactivation curves were shifted to depolarized voltages. The effects of Z...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: eneuro
سال: 2016
ISSN: 2373-2822
DOI: 10.1523/eneuro.0038-16.2016